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By 6 hours after treatment, muscle tone in the 8 and 16 mg Zanaflex groups was indistinguishable from muscle tone in placebo treated patients. In patients with renal insufficiency (creatinine clearance 25 mL/min) clearance was reduced by more than. Tablets are provided as follows: bottles of 150 tablets ( NDC ). Following single and multiple oral dosing of 14C-tizanidine, an average of 60 and 20 of total radioactivity was recovered in the urine and feces, respectively. It is not known whether Zanaflex will harm an unborn baby. Zanaflex Consumer real Information Low Back Pain Slideshow Take the Back Pain Quiz! Do not take extra medicine to make up the missed dose. The CNS depressant effects of tizanidine and alcohol are additive. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Figure 2 below shows a comparison of the mean change in muscle tone from baseline as measured by the Ashworth scale. It is not recommended that Zanaflex be used with other 2- adrenergic agonists. In some circumstances, tizanidine might be used safely in this case. Do not take more than three doses (36 mg) in a 24-hour period. Pain from fibromyalgia can have a severe impact on your quality of life, making even normal tasks difficult. In all, 264 patients received tizanidine and 261 patients received placebo. For instance, both drugs interact with central nervous system (CNS) depressants like alcohol, narcotics, and benzodiazepines. See dosage AND administration and Use In Specific Populations Withdrawal Adverse Reactions Withdrawal adverse reactions include rebound hypertension, tachycardia, and hypertonia. 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